Orlistat also known as tetrahydrolipstatin is a poorly water soluble drug designed to treat obesity. Its primary function is preventing the absorption of fats from the human diet, thereby reducing caloric intake. Solid dispersion is used to reduce the particle size and to increase the rate of dissolution and absorption. Such as microcrystalline dispersion of poorly soluble drug in matrix consisting of physiologically inert soluble solids such as cyclodextrins as carriers which accommodates poorly water soluble drug like Orlistat. The objective of the present study is to enhance bioavailability by increasing solubility using various techniques such as Kneading method, Fusion method and Trituration method by varying concentration of drug: β-CD. The formulated solid dispersions are evaluated for drug content (98.65%), in- vitro drug release (48%) in water as well as in compendial media. FT-IR, DSC shows presence of drug and absence of interaction between drug and carrier. Thus the solid dispersion formulations could be a promising delivery system for Orlistat with improved solubility, absorption and oral bioavailability.
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